Total Antioxidant Capacity level in Radiation Workers and other Staffs of Hospital in Sistan and Baluchestan Province

Introduction: Human’s body and other creatures fight with destructive factors, as well as other factors that threaten human health and life. There is an antioxidant biological system in living organisms to face oxidizing compounds. In this immune system, compounds are found that react directly with oxidizing agents and make them neutral. The variety of compounds are included compounds with low molecular weight antioxidants such as vitamins E, C. For any reason that serum or intracellular antioxidants decreases, oxidizing substances that released and remain active can damage cell. To assay the total antioxidant capacity (TAC) of radiation workers serum in diagnostic radiology centers of Zahedan city in I.R.Iran.     Materials and Methods: This case-control study was conducted by 41 case radiation workers and 81 controls between June 2016 and February 2017, in biochemistry Laboratory of Zahedan university of medical science. Case persons were taken from radiation workers who didn’t go vacation in the past month and control from staffs of other parts of centers with the least probability of man-made radiation exposure. Case-control arms matched in age, gender and economic situation. Then 5 ml whole blood was taken from each of them. For measurement TAC of serum, we used FRAP assay (Ferric Reducing Ability of Plasma). p values <0.05 were considered as statistically significant.   Results: Mean capacities of antioxidant were 801.3 and 879.89 µmol/L for control and case groups respectively. It was not statistically significant (p = 0.062). There was statistically significant relation with gender (p = 0.021, F = 0.96). Average level was measured 941.21 ± 149.10 and 826.95 ± 93.96 µmol/L for men and women respectively.   Conclusion: It seems that antioxidant systems are effective in deactivating produced free radicals. It can be concluded exposure to radiation was not amount to have significant effect on TAC of persons in this study. It matched data extracted from film badge dose meters. Antioxidant level was higher in men than women, because of higher uric acid of serum